On April 14, 1741, the congregation was organized by Johann Martin Boltzius, who was the pastor for the Salzburger emigrants in Ebenezer, Georgia.

[1] In 1756, the congregation purchased the land where the current building stands, adjacent to Wright Square.

[1] In 1774, noted Lutheran pastor Henry Muhlenberg preached to a congregation of about 200 in the building.

[4] This building features a large stained glass window depicting the ascension of Jesus.

[1][5] During the American Civil War, the church served as a field hospital, and Union soldiers occupied the building.