Luthersville is a city in Meriwether County, Georgia, United States.

U.S. Route 27 Alternate is Luthersville's Main Street; the highway leads south 13 miles (21 km) to Greenville, the Meriwether county seat, and north 12 miles (19 km) to Newnan.

Georgia State Route 54 crosses US 27 Alternate in the center of Luthersville; it leads northeast 11 miles (18 km) to Turin and southwest the same distance to Hogansville.

The northwest part of the city drains to Yellowjacket Creek, a tributary of the Chattahoochee, while the southern part of the city drains to Coleman Creek and the northeast part drains to Bear Creek, both tributaries of the Flint.

As of the 2020 United States census, there were 776 people, 248 households, and 173 families residing in the city.