While the monastery building remains nearly as it was designed, the church has been rebuilt many times; the apse and reconstructed dome are its only original parts.

In 16th-century Rus', a hospital, the church of Saint Lazar and a cemetery were located on the northern side of Lutsk Island near Glushets bridge; they were destroyed by fire in 1619.

Since it was impossible to build all the required infrastructure in their own area, the Fellowship purchased neighbouring lands.

In 1645, King Władysław IV Vasa authorized a new brick hospital and administrative house with the aid of Olexandr Mozelli.

In 1647, two-story houses (a school, hospital, library, print shop and monastic cells) were completed.

The iconostasis, consisting of 16 icons, was originally made of carved oak and gold leaf during the 19th century.