It both serves local traffic and connects to the Reading Blue Mountain and Northern Railroad in Pittston and to the Norfolk Southern Railway at three separate junctions.
It operates a total of 55 miles of track in and around the Wyoming Valley in Luzerne County.
Major commodities hauled by the Luzerne and Susquehanna include chemicals, packaging, building products, and food & beverage.
The Luzerne and Susquehanna Railway is headquartered at 25 Delphine Street in Owego, New York, as part of a holding company for three shortline railroads in the Twin Tiers along with a disjunct shortline railroad in Mississippi.
The line's tracks are owned by the Luzerne County Redevelopment Authority.