[6] As of the 2020 United States census, there were 2,249 people, 656 households, and 529 families residing in the city.

The United States Postal Service operates the Lyford Post Office.

Lyford's economic fortunes have been linked intimately with that of Mexico's after NAFTA went into effect on January 1, 1994.

Prior to ratification of this agreement, economic activity in Lyford was centered on agriculture.

In addition to the industrial activity, there is a retail sector that is dependent on purchases made by wealthy and middle-class Mexican consumers from Monterrey (connected to Reynosa by toll road) and Tampico.

According to Cynthia Brown, director of UTPA's Center for Border Economic Studies, Mexicans invested $1.4 billion into the economy and paid for 41,000 jobs[1].