[7] Signs and symptoms may include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired.

[9] Lymphomas, leukemias and myelomas are a part of the broader group of tumors of the hematopoietic and lymphoid tissues.

[11] Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family.

[1] Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, immunosuppressant medications, and some pesticides.

[2][12] Eating large amounts of red meat and tobacco smoking may also increase the risk.

Lymphoma is definitively diagnosed by a lymph-node biopsy, meaning a partial or total excision of a lymph node examined under the microscope.

These include: According to the World Health Organization (WHO), lymphoma classification should reflect in which lymphocyte population the neoplasm arises.

Hodgkin lymphoma is considered separately within the WHO and preceding classifications, although it is recognized as being a tumor, albeit markedly abnormal, of lymphocytes of mature B cell lineage.

The prognosis, therefore, depends on the correct diagnosis and classification of the disease, which is established after examination of a biopsy by a pathologist (usually a hematopathologist).

These diseases do not progress to cancer, may regress spontaneously and do not respond to, and do not require, chemotherapy or other lymphoma treatments.

Many low-grade lymphomas remain indolent (growing slowly or not at all) for many years – sometimes, for the rest of the person's life.

People with these types of lymphoma can live near-normal lifespans, even though the disease is technically incurable.

Some centers advocate the use of single agent rituximab in the treatment of follicular lymphoma rather than the wait-and-watch approach.

Watchful waiting is not a desirable strategy for everyone, as it leads to significant distress and anxiety in some people.

can result in a cure in the majority of cases, but the prognosis for people with a poor response to therapy is worse.

[52] Treatment for these types of lymphoma typically consists of aggressive chemotherapy, including the CHOP or R-CHOP regimen.

[53] For people who relapse, high-dose chemotherapy followed by autologous stem cell transplantation is a proven approach.

[54] The treatment of side effects is also important as they can occur due to the chemotherapy or the stem cell transplantation.

Encouragingly, a significant number of people who relapse after ABVD can still be salvaged by stem cell transplant.

[61] Scientists evaluated whether positron emission tomography scans between the chemotherapy cycles can be used to make assumptions about the survival.

[64][65] It is used to address both the direct symptoms of lymphoma and many unwanted side effects that arise from treatments.

[73] Lymphoma is the most common form of hematological malignancy, or "blood cancer", in the developed world.

The term "lymphoma" is from Latin lympha ("water") and from Greek -oma ("morbid growth, tumor").

Clinical/translational research focuses on studying the disease in a defined and generally immediately applicable way, such as testing a new drug in people.

Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for people, or appropriate care in remission or after cures.

The results from basic research studies are generally less immediately useful to people with the disease,[81] but can improve scientists' understanding of lymphoma and form the foundation for future, more effective treatments.