The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD.
[1] The chemical agents used are: Drug Regimen[2][3] The chemotherapy part of Stanford V treatment can last anywhere from 8 to 12 weeks, depending on the staging of the disease.
In many cases, this is followed by radiation therapy for anywhere from 2 to 6 weeks to the affected areas of the body.
Specifically, the radiation therapy component following chemotherapy was not properly administered in the Italian study.
The study concluded that, "Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL.