The Großes Mühlsturzhorn is 2,234 m above sea level (NHN) and its top is around 300 metres southeast of the Stadelhorn, not far from the border between Bavaria and Salzburg in Austria.

The Kleines Mühlsturzhorn is located 280 metres east-northeast and has a height of 2,141 m above NHN.

On 8 September 1999, 250,000 m3 (330,000 cu yd) of rock broke off in the summit area of the Kleines Mühlsturzhorn and crashed into the Klausbach valley.

The unmarked normal route to the Großes Mühlsturzhorn runs from the northwest via the Mayrbergscharte gap and the Stadelhorn (grade II).

Well known climbing tours are the Alte Südkante (grade VII-, first climbed in 1930 by Huber and Mitterer) and the Direkte Südkante (VI/A1 or VIII-, first achieved in 1936 by Anderl Hinterstoißer and Toni Kurz shortly before Kurz's death on the north face of the Eiger).