The highway runs along a series of streets in Allegan and through rural farm fields and woods between the two communities along 116th Avenue.

Then the highway proceeds through residential areas along Monroe and turns onto Grand Street to cross over the Kalamazoo River.

From there, the highway continues on due eastward as 116th Avenue through rural areas and agricultural fields.

[6] No section of M-222 is listed on the National Highway System,[7] a network of roads important to the country's economy, defense, and mobility.

[14][15] In 1988,[disputed – discuss] the M-118 designation was decommissioned and the highway was renumbered M-222 to prevent confusion with 118th street which runs parallel to the route about one mile (1.6 km) to the north for most of the length.