The Methuselah Foundation is an American-based global non-profit organization based in Springfield, Virginia, with a declared mission to "make 90 the new 50 by 2030" by supporting tissue engineering and regenerative medicine therapies.

The new name was introduced at the 32nd Annual Meeting of the American Aging Association,[3] where they awarded the first Methuselah Mouse Prize to Andrej Bartke for his work on mice that lived the equivalent of 180 human years.

[5] The entity operates as the mechanism through which the Foundation turns its vision into reality by identifying young companies whose research promises to transform the human lifespan, providing them with seed funds to underwrite their work and supporting them with ongoing business counsel.

However, unlike those organizations, it is primarily focused on maximizing what it calls "return on mission", which it defines as extending the healthy human lifespan.

Gobel and Ruiz have led investments in: In 2016, NASA in partnership with the New Organ Alliance announced the Vascular Tissue Challenge.

[24][25] Creating a sufficient blood vessel system – vasculature – is often seen by biomedical researchers as a primary impediment in engineering thick tissues.

[28][29] The Alliance for Longevity Initiatives, whose mission is to create social and political action around the issue of combating age-related chronic conditions and increasing our number of healthy, disease-free years.

[30] The organization seeks to build policies that encourage economic and scientific support for more longevity solutions, such as bioengineered patient trials and dramatically improved biomedical research models that use engineered human tissue.

Aging is a leading risk factor for most common neurodegenerative diseases, including strokes, brain tumors, aneurysms, cognitive impairments and dementias.

[24][25] Creating a sufficient blood vessel system – vasculature – is often seen by biomedical researchers as a primary impediment in engineering thick tissues.

With this disease, a defective protein "amasses in and clogs blood vessels, forcing the heart to work harder and eventually fail.

"[64][65] From 2003 to 2009,[2] Methuselah Foundation served as the backbone organization for the strategies for engineered negligible senescence (SENS) program, a long-term research framework developed by Aubrey de Grey.

[69] Additionally, Methuselah sponsored a series of SENS-focused roundtables and conferences,[70] and funded the writing of Ending Aging, co-authored by de Grey and Michael Rae.

On September 16, 2006, Peter Thiel, co-founder and former CEO of the online payments system PayPal, announced that he was pledging $3.5 million to the Methuselah Foundation and the SENS programs "to support scientific research into the alleviation and eventual reversal of the debilities caused by aging".