M. Amin Arnaout is a Lebanese physician-scientist and nephrologist best known for seminal discoveries in the biology and structure of integrin receptors.

He is Professor of Medicine at Harvard Medical School and Physician, former Chief of Nephrology, and Director of the Leukocyte Biology and Inflammation Laboratory at the Massachusetts General Hospital (MGH).

[20] His two research papers published in the journal Science are the two most quoted in the integrin field for the past 20 years.

He was also the first to identify the antigen targeted by autoantibodies in patients with systemic vasculitis,[23] which formed the basis for a routinely used diagnostic assay.

He was the first to show that polycystin-1, one of two gene products mutated in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), is required for the structural integrity of blood vessels,[24] indicating that the early onset of high blood pressure and presence of vascular aneurysms in ADPKD is caused by a primary defect in vascular polycystin-1.