[2] Gurupadaswamy was a member of Rajya Sabha for 4 terms from Mysore from 1960 to 1966, from Uttar Pradesh from 1966 to 1972 and from Karnataka from 1984 to 1990 and from 1990 to 1992.

He was Minister of Agriculture and Food, Community Development and Cooperation in Indira Gandhi's Cabinet during 1967–69.

[2] In 1969, when Congress split, Gurupadaswamy was one of the first Ministers to resign from Indira Gandhi's cabinet.

[2] Gurupadaswamy served as Minister of Petroleum and Chemicals in V. P. Singh Ministry from 1989 to 1990.

[2] Gurupadaswamy published two books, namely Modern Trends in International Affairs and Communalism.