[3]: 107  Here the route becomes one-way as Pixley Seme Street heading north through the city with Newtown to the west.

[3]: 107  Turning right, its joined by traffic crossing the Nelson Mandela Bridge and its heads north through to the top of Braamfontein ridge as Bertha Street.

[3]: 107  It passes the East campus of the University of Witwatersrand on its left and Helpmekaar Kollege on the right before descending into the leafy suburb of Parktown where it crosses over a major intersection with the M71 Empire Road.

[3]: 81  After crossing Empire Road, passes over the M1 De Villiers Graaff motorway again with several entrances and exits at this intersection.

[3]: 55  It then enters the old Randburg suburbs of Blairgowrie and Bordeaux intersecting Bram Fischer Drive in Ferndale where the M27 Jan Smuts Avenue ends.