It may have played a key role in the evolution of humans from apes.

[8] MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate.

MAD1L1 may play a role in cell cycle control and tumor suppression.

[9][10][11] Three transcript variants encoding the same protein have been found for this gene.

[7] MAD1L1 has been shown to interact with: This biochemistry article is a stub.