MADAM-6, or 2, N-dimethyl-4,5-methylenedioxyamphetamine, is a lesser-known recreational drug of the methamphetamine class, similar in structure to MDMA (ecstasy).

[2] In Shulgin's book PiHKAL, the minimum dosage is listed as greater than 280 mg, and the duration is unknown.

[2] MADAM-6 produces few to no effects and Shulgin describes it as "not active".

[2] Very little data exists about the pharmacological properties, metabolism, and toxicity of MADAM-6.

[3] However, no clinical trials suggest the drug is effective against Parkinson's disease.