[5][6][7] The product of this gene functions in the NF-kappaB signal transduction pathway.

The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1.

Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor.

Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

This article on a gene on the human X chromosome and/or its associated protein is a stub.