2DAE, 2WWZ, 2WX0, 2WX12311868652ENSG00000055208ENSMUSG00000015755Q9NYJ8Q99K90NM_001292034NM_001292035NM_015093NM_145342NM_001369506NM_138667NM_001359534NP_001278963NP_001278964NP_055908NP_001356435NP_619608NP_001346463Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.

[5][6][7] The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK.

This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6.

This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.

[7] Mutations in MAP3K7IP2 have been associated with human congenital heart defects.