2RQB, 3B6E, 3GA3, 4GL26413571586ENSG00000115267ENSMUSG00000026896Q9BYX4Q8R5F7NM_022168NM_001164477NM_027835NP_071451NP_001157949NP_082111MDA5 (melanoma differentiation-associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that is encoded by the IFIH1 gene in humans.

[9] Some observations made in cancer cells show that MDA5 also interacts with cellular RNA is able to induce an autoinflammatory response.

[18] Another hinge region connects the C-terminal domain (CTD) which is responsible for the recognition and the binding of RNA.

They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.