MHC class III

It was later found that it contains many genes for different signaling molecules such as tumour necrosis factors (TNFs) and heat shock proteins.

[2] The region previously considered within MHC class III gene cluster that contains genes for TNFs is now known as MHC class IV[3] or inflammatory region.

[4] In contrast to other MHC proteins, MHC class III proteins are produced by liver cells (hepatocytes) and special white blood cells (macrophages), among others.

MHC class III genes are located on chromosome 6 (6p21.3) in humans.

[5] Many retroelements such as human endogenous retrovirus (HERV) and Alu elements are located in the cluster.