MIL-STD-1750A or 1750A is the formal definition of a 16-bit computer instruction set architecture (ISA), including both required and optional components, as described by the military standard document MIL-STD-1750A (1980).
I/O is generally via the I/O instructions (XIO and VIO), which have a separate 216 16-bit word address space and may have a specialized bus.
1750A systems often offer high levels of protection from radiation and other hazardous environments, making them particularly suited for military, aviation and space applications.
This includes embedded tasks such as aircraft and missile control systems as well as more mundane general military computing needs.
The advantages of this concept are recognized outside of the USAF, and the 1750A has been adopted by other organizations such as the European Space Agency, NASA, Israeli Aircraft Industries, and many projects in academia.