[3] MT-TL1 is a small 75 nucleotide RNA (human mitochondrial map position 3230–3304) that transfers the amino acid leucine to a growing polypeptide chain at the ribosome site of protein synthesis during translation.
[5] MELAS is a rare mitochondrial disorder known to affect many parts of the body, especially the nervous system and the brain.
Additional symptoms include muscle weakness (myopathy) and various problems with a patient's eyes, heart, or kidneys.
Phenotypes of the condition include encephalopathy, epilepsy, dystonia, hypotonia, myalgia, exercise intolerance, and more.
[11] This article incorporates text from the United States National Library of Medicine, which is in the public domain.