For the first time, a four-cylinder engine was fitted transversely to the direction of travel on a standard motorbike and cable-operated disc brakes were used.

[1] Dr. Pietro Remor designed a racing engine for MV Agusta for the World Motorcycle Championship based on the Gilera four-cylinder, for which he was previously responsible.

[6] Particularly striking was the fine ribbing of the cooling fins on the sump and the oversized cylinder head housing the double camshaft drive.

[13] The blue special was made for Vittorio Emanuele, Prince of Naples as a thank you for brokering a deal for Agusta helicopters with the Shah of Iran.

[15] The Austrian, Wolfgang Stropek, finished tenth (although 3 laps behind Giacomo Agostini on the works MV Agusta 500 Three)[16] in the 1969 Finnish 500 GP.

The bike was equipped with a fairing, a final chain drive and a reduced displacement engine in order to fit within the 500 cc category limit.

[17][18] The most well-known special based on MV 600 is the one that Massimo Tamburini created in 1971[19] when Bimota (of which he was one of the founding partners) was a company that dealt with heating and air conditioning.

[21] The Rimini designer created the bike during his spare time starting with a second-hand 600, which was the subject of extensive work on the chassis, mechanics and aesthetics.

This reworking gained the appreciation of the enthusiasts (including Angelo Bergamonti, who tested it on the occasion of a visit to Cascina Costa di Tamburini) and the disapproval of Count Domenico Agusta, who did not like these modifications of his machines.