Wayne performed as a concert pianist and singer, and as a dancer in vaudeville.

[3] In the 1920s and 1930s she collaborated with several lyricists including L. Wolfe Gilbert, Sam M. Lewis and Joe Young.

[1] After a short-lived marriage in the 1910s, Mabel Wayne married Nick Campbell, a music publisher based in New York, on March 15, 1948 in the Little Church of the West, located in Reno, Nevada.

Lanny Ross and his wife served as the best man and matron of honor.

[3] Mabel Wayne died at Glen Cove, Long Island, in 1978 at the age of 87.