Macarthur FC's first team have competed in the A-League Men.
Macarthur FC's first A-League Men match was against Western Sydney Wanderers, and they have met 11 different league opponents in the 2020–21 A-League season.
The team that Macarthur FC have played most in league competition is Central Coast Mariners; the 5 defeats from 9 meetings is more than they have lost against any other club.
Western United have drawn 3 league encounters with Macarthur FC, more than any other club.
Macarthur FC have recorded more league victories against Perth Glory than against any other club, having beaten them 4 times.