The purpose of the office is to provide services and assistance to Macau residents who work, study, travel, conduct business, live or may encounter emergencies in Taiwan.

It also promotes exchanges and cooperation between Macau and Taiwan in trade, tourism, technology, environmental protection, education, health, cultural activities, academic publishing, technical specialty, social welfare and other areas.

On 13 May 2012, Lai celebrated the opening ceremony of Macau Economic and Cultural Office in Taiwan.

Lai was accompanied by Cheong U, Secretary for Social Affairs and Culture of the Macau SAR.

Lai added that the office establishment resulted from the principle of goodwill and reciprocity held by both sides and it was considered a milestone in the development for bilateral relation between Taiwan and Macau.