The Mackenzie Mountains are a Canadian mountain range forming part of the Yukon–Northwest Territories boundary between the Liard and Peel rivers.

The range is named in honour of Canada's second prime minister, Alexander Mackenzie.

The highest mountain in this range is Keele Peak at 2,952 m (9,685 ft), in Yukon.

It is, at 2,773 m (9,098 ft), the highest mountain in the Northwest Territories.

The Silurian fish family Archipelepididae has been described from specimens found in the Mackenzie Mountains.