The road crossed the Noxubee River just west of Macon, located at the old Choctaw village of Taladega, now the site of the local golf club.

The road declined in importance in the 1840s, largely due to the difficulty of travel in the swamps surrounding the Noxubee River in and west of Macon.

The route for the most part was replaced by the Robinson Road, which ran through Agency and Louisville before joining the Natchez Trace, bypassing Macon.

[3] On September 15, 1830, US government officials met with an audience of 6,000 Choctaw men, women and children at Dancing Rabbit Creek to explain the policy of removal through interpreters.

The Choctaws faced migration west of the Mississippi River or submitting to U.S. and state law as citizens.

[6] The city served as the capital for the state of Mississippi during the Civil War from 1863 onward.

[11] According to the United States Census Bureau, the city has a total area of 1.5 square miles (3.9 km2), all land.

[14] As of the 2020 United States Census, there were 2,582 people, 1,110 households, and 724 families residing in the city.

[21] The City of Macon is now served by the Noxubee County School District.

East Mississippi Community College offers some courses at Noxubee County High School in Macon.