[1] Macrocranion is a genus of extinct mammal from the Eocene epoch of Europe and North America.

[3] Macrocranion species are often described as forest-floor predators, about the size of small squirrels but with longer limbs.

Although possibly an omnivore, fossil remains indicate the specimen had eaten fish near the time of its death.

This small animal was approximately fifteen cm in length, with long back legs capable of considerable speed.

The oldest species are M. vandebroeki from the Paleocene-Eocene transition of Northern Europe and M. junnei from the Wasatchian (Early Eocene) of Wyoming.