Macrogol

Macrogol, also called polyethylene glycol (PEG), is used as a laxative to treat constipation in children and adults.

[24][25] Macrogols are also attached to biopharmaceutical drugs to slow down their degradation in the human body and increase their duration of action, as well as to reduce immunogenicity.

Absorption of other pharmaceutical drugs can be reduced because oral macrogol accelerates intestinal passage, but this is seldom clinically relevant.

[18] Macrogol is an osmotically acting laxative; that is, an inert substance that passes through the gut without being absorbed into the body.

This increases the water content and volume of the stools in the bowel, making them softer and easier to pass, as well as improving gut motility.

Brand names include CosmoCol, Cololyt, Glycoprep, Laxido, MiraLax, Molaxole, Movicol, and Osmolax.

Polyethylene glycol-electrolyte solution is a fixed-dose combination medication sold under various brand names in the US, including Colyte,[33] Gavilyte, Golytely,[34] Nulytely,[35] Moviprep,[36] and Trilyte.

[37][38] Brand names available in the UK include CosmoCol, Klean-Prep, Laxido, Molaxole, Movicol, Plenvu,[1] TransiSoft, and VistaPrep.

This makes for a longer-acting medicinal effect and reduces toxicity, and it allows for longer dosing intervals.

[18] There is evidence demonstrating PEG-induced repair of specific nerve cells in animal models:

A polyethylene glycol (PEG) and electrolytes solution used as a laxative used to cleanse the colon before colonoscopy , lower gastrointestinal series , or colon surgery.
Macrogol 4000, pharmaceutical quality
The protein uricase can be PEGylated to form pegloticase , which improves its solubility at physiological pH , increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer , lower images show one of the lysines that is PEGylated. ( PDB : 1uox ​ PEG-uricase model from reference [ 41 ] )