D. nezumiae are similar in body shape to smaller Diclidophora species, with shorter bodies that taper to a maximum width at the first pair of clamps; 8 posterior clamps in total.

Unlike other Diclidophora species, D. nezumiae have clamps that are wider than they are long, relatively small clamp suckers, postovarian testes and unlobed seminal receptacle on right side of ovary.

The parasite is highly localized, affecting deep living benthic fish.

The fish Nezumia bairdii in the Hudson Submarine Canyon, off the coast of New York City and Long Island, is the known host for this species, with an approximate 30% prevalence among fish and common infections incurring low numbers of parasites ranging up to 20 per host.

Symptoms may include those similar to other monogeneans, such as Dactylogyrus, with inflamed gills, excessive mucous secretion, and accelerated respiration.