Mad Professor Mariarti is a puzzle-platform game developed and published by Krisalis Software in 1990.

Mariarti must shut down his laboratories in order to end the chaos, prove his sanity and avoid being put into a psychiatric hospital.

In each laboratory, Mariarti must find and use a number of items in order to open up new areas and eventually to shut down the room.

Examples of items and how they are used are: A number of enemy characters are seen in the game, mostly themed around the laboratory in which they are situated (e.g. walking floppy disks and joysticks in the Computer Laboratory, round-bottom flasks and molecular models in the Chemical Research Dept, and mutant plants and animals in Biological Observations).

There are also static obstacles that either drain the Professor's health gradually (such as puddles of acid) or kill him instantly if touched (such as electric zappers of various designs).