Notable celebrity appearances this season include: Pamela Anderson (who hosted the show's 250th episode, is one of many celebrities who not only hosted Saturday Night Live, but also cameoed on MADtv, and was lampooned by both shows fairly frequently), Jeff Garlin, Alyson Hannigan, Neil Patrick Harris, Jaime Pressly, Michael Rapaport, John Cena, Jeff Probst, Pauly Shore, and Fred Willard The title sequence opens with the Mad TV logo appearing against the skyline of Los Angeles.
Backstage, Michael McDonald receives hate mail from a kid and Frank Caeti is mistaken for Frank Caliendo; Ike Barinholtz and Bobby Lee conduct red-carpet interviews at the Mad TV season 11 premiere; Jessica Simpson (Parker) sings about the horrible film remakes of classic TV shows; a parody of House in which Dr. House (McDonald) pops Vicodin and cruelly treats a dying marriage counselor (Caeti); Mrs. Campbell (Weir) robs a saleslady (Flanagan) of the chance to make a sale by showing a couple (Caeti, Parker) a better home; Morgan Freeman (Peele) follows up March of the Penguins with a film about the animals in his backyard; two nerdy craft ladies (Flanagan, Myrin) sell Popsicle houses; a new thriller called The Psychiatrist is packed with unlikely stars (Caliendo, Flanagan, Parker); OK Go perform "A Million Ways".
Featuring: Frank Caeti, Nicole Randall Johnson George W. Bush (Caliendo) raps with the Black Eyed Peas (Parker, Peele, Lee, and Key) about the failures and scandals of his administration; Britney Spears (Parker) and Kevin Federline (Barinholtz) clear the air about their much-publicized life; Mofaz (McDonald) comforts a reluctant new father (Barinholtz) while at the hospital; a parody of Sesame Street in which Big Bird (Peele) gets the bird flu; Ike Barinholtz and Bobby Lee conduct interviews of celebrities at the Billboard Music Awards; Jeff Garlin plays the temporary new host of the Lillian Verner Game Show; a dysfunctional family (Caeti, Caliendo, Flanagan, McDonald, Myrin, Parker) is serenaded by caroling rappers (Gaither, Johnson, Key, Peele) at Fuddermucker's.
Movie trailer for Memoirs of a Geisha derides the movie for being a pretentious Cinderella story with a Japanese prostitute (Lee); Fox becomes intrusive disrupting guest star Neil Patrick Harris's cold open on stage with promos for series such as King of the Hill, That '70s Show, Cops, 24 and Stacked; Stuart Larkin (McDonald) visits a mall Santa (Caeti); Sean Gidcomb (McDonald) retires and introduces his employees to his replacement (Neil Patrick Harris); on Inside Looking Out, the LaMantroses (Peele, Parker) sing "Kwanzmas Carols"; Denise (Flanagan) and Krista (Myrin) meet twin brothers (Caliendo, Caeti) while selling crafts at a rodeo.
A look at Action 5 News' large anchor team; Katie Holmes (Parker) feels trapped in her relationship with Tom Cruise; Bae Sung (Lee) annoys John Madden (Caliendo) during a football game; the Blind Kung Fu Master (Lee) tries to save an old woman (Gaither) from jive-talking muggers (Barinholtz and Peele); the Superstitious Knights (Key, Peele) break hexes at a casino; a parody of Laguna Beach; Michael Rapaport stars in a gritty Abraham Lincoln bioseries on HBO; the author of a home remedy book (McDonald) lies his way through his sales pitch during an infomercial; Steven Cragg helps make a wish come true for a woman's elderly uncle -- with disastrous results.
Hilary Duff (Myrin) sings about how she (and other stars like her) becomes anorexic to stay in the spotlight; Reese Witherspoon (Myrin) presents deleted footage from her film Walk the Line; Montel Williams (Peele) gets high while interviewing an abuse victim (Parker); Larry King makes lewd comments in his review of Deadwood; Ike Barinholtz and Bobby Lee teach Jordan Peele how to drive; a parody of Grey's Anatomy has personal drama get in the way of medical duty; nervous comic Luann Lockhart (Flanagan) performs her stand-up routine.
A lonely wife (Parker) sleeps with the Hamburger Helper Hand; deadpan sociopath Yvonne Criddle (Gaither) freely admits she threatened to kill a man (Key) for taking her parking spot; the Blind Kung Fu Master (Lee) meets his equally visually challenged nemesis (Caliendo); lesbians (Flanagan, Gaither) think that a new lover (McDonald) of their friend (Myrin) is actually a man in drag; Eugene Struthers (Key) interviews the cast of Ice Age: The Meltdown; an innocent conga line at a wedding turns into a never-ending chain of people; three shoe store women (Flanagan, Johnson, Myrin) try to express their personal opinions to other people but they can't open it up to it; show writer Steven Cragg shows off his zombie band sketch.