Damiella Nomenjanahary and Éric Andriantsitohaina were chosen to be Madagascar's flag bearers during the Parade of Nations of the opening ceremony.

[6] Todisoa Rabearison finished eighth in his heat for the Men's 400 metres with a time of 48.40, his season's best, but 1.6 seconds slower than his personal best, and did not advance.

[7][8][9] Madagascar qualified one judoka for the women's half-middleweight category (63 kg) at the Games.

Damiella Nomenjanahary accepted a continental berth from Africa as the nation's top-ranked judoka outside of direct qualifying position in the IJF World Ranking List of June 28, 2021.

Brothers Éric Andriantsitohaina (men's 61 kg) and Tojonirina Andriantsitohaina (men's 67 kg) both topped the field of weightlifters from the African zone in their respective weight divisions based on the IWF Absolute Continental Rankings.