After her death, the title was borne by her younger sister, Christine de Bourbon (1606–1663), until her marriage to Victor Amadeus I, Duke of Savoy (1587–1637).
The most famous holder of this honorific was King Louis XVI of France's eldest daughter, Marie-Thérèse-Charlotte (1778–1851), the only one of his immediate family to survive the French Revolution.
She later married her cousin, Louis-Antoine, duc d'Angoulême (1775–1844), and played a prominent role during the Bourbon Restoration.
This title came into existence when Queen Henrietta Maria (1609–1669), another daughter of King Henry IV of France, and the wife of King Charles I of England (1600–1649), wanted to imitate in the Kingdom of England the way in which the eldest daughter of the sovereign in France was styled Madame Royale.
In Savoy, Henrietta Maria's older sister, Christine de Bourbon, became known as Madama Reale in reference to her French manner of address.