It has been serialized online in Takeshobo's digital publication Web Comic Gamma since October 2012, and has been collected in 13 tankōbon volumes.

A second season, titled Made in Abyss: The Golden City of the Scorching Sun, aired from July to September 2022.

A Western live-action film adaptation began development in 2021, with Kevin McMullin hired to write and direct.

An action role-playing game developed by Chime Corporation and published by Spike Chunsoft was released in September 2022.

The Abyss harbors artifacts and remnants of civilizations long gone, and is, therefore, a popular hunting spot for so-called Cave Raiders, who undertake arduous and dangerous descents into the mist-filled pit to recover whatever relics they can find.

Some legendary Cave Raiders earn the title of White Whistles, one of them being Riko's mother, Lyza, who is presumed dead after taking a "last descent" into the Abyss.

Riko, determined to find her mother, bids farewell to her friends and secretly departs into the Abyss with Reg as her companion.

Written and illustrated by Akihito Tsukushi, Made in Abyss started on Takeshobo's Manga Life Win+ (later Web Comic Gamma) website on October 20, 2012.

[20] The series was directed by Masayuki Kojima and written by Hideyuki Kurata, with animation by Kinema Citrus and character designs by Kazuchika Kise.

[23] Two compilation films, titled Made in Abyss: Tabidachi no Yoake (メイドインアビス 旅立ちの夜明け, "Journey's Dawn") (encompassing episodes 1–8 with new scenes for introduction) and Made in Abyss: Hōrō Suru Tasogare (メイドインアビス 放浪する黄昏, "Wandering Twilight") (encompassing episodes 9–13), were released on January 4 and 18, 2019, respectively.

[26][27] The film had been set to premiere in the United States at Anime Boston on April 11, 2020, before that convention's cancellation due to the COVID-19 pandemic.

[35] Sentai Filmworks has licensed the series, and streamed it on Amazon's Anime Strike service in the US, and on Hidive in other territories.

[43] During its panel at Anime Expo on July 5, 2019, Sentai Filmworks announced that they had acquired the license for Dawn of the Deep Soul.

[45][46] Sentai Filmworks also acquired the second season for distribution worldwide except Asia, France, Germany, Italy and Middle East and North Africa, and streamed it on select digital outlets.

[47] An action role-playing game, titled Made in Abyss: Binary Star Falling into Darkness (メイドインアビス 闇を目指した連星, Made in Abyss: Yami o Mezashita Rensei), was developed by Chime Corporation and published by Spike Chunsoft, with Numskull Games publishing the physical versions in Europe.

The game was released on Nintendo Switch, PlayStation 4, and Windows on September 1, 2022, in Japan, and the following day in North America and Europe.

[51] In 2018, Made in Abyss was nominated for the 11th Manga Taishō award and received a total of 40 points, coming in at eighth place.