Madhumitha started her acting career under her birth name Swapna Madhuri with the 2002 Telugu film Sandade Sandadi (2002) doing a pivotal supporting role.
She continued playing supporting roles in a couple of Telugu films like Manmadhudu (2002) along with Nagarjuna and Sonali Bendre, Ammayilu Abbayilu (2003) and Puttintiki Ra Chelli (2004) sharing screen space with Arjun and Meena, with the latter in particular becoming a high commercial success, running for 275 days in theatres.
She was next seen in Yogi, opposite director-turned-actor Ameer Sultan, Madhumitha's role was unanimously praised with a reviewer from Rediff.com citing that "Madhumitha, taking on a role even experienced actresses might balk at and coming out trumps" Her performance as a young mother living in the Chennai slums, was critically praised,[3][4] winning her a nomination for the Best Supporting Actress Award at the 3rd Vijay Awards.
Post her marriage, she played supporting roles in Venkat Prabhu's Biriyani and the Telugu films Uu Kodathara?
Madhumitha married her longtime boyfriend, actor Siva Balaji on 1 March 2009 at Kalinga Function Place in Hyderabad, Telangana.