Pathological fractures can arise in affected metaphyses and diaphyses of the long bones and are common (26%).

The risk for sarcomatous degeneration of enchondromas, hemangiomas, or lymphangiomas is 15–30% in the setting of Maffucci syndrome.

[5] Multiple enchondromas may present in three disorders: Ollier disease, Maffucci syndrome, and metachondromatosis.

Ollier disease is more common than Maffucci syndrome, and presents with multiple enchondromas often in a unilateral distribution.

[6] Metachondromatosis demonstrates autosomal-dominant transmission and presents with both multiple osteochondromas and enchondromas.