Magnolia was founded in 1856 by Ansel H. Prewett, a local civic leader and cotton planter.

Prewett, while serving as temporary sheriff of Pike County, was killed by outlaws in the early 1870s escorting a prisoner on the very railroad that made Magnolia a viable community.

At one time early Magnolia boasted an opera house, skating rink, and several hotels that catered largely to these tourists.

In 1860 Magnolia's first newspaper, the Grand Trunk Magnolian, was established by John Waddill.

[25] The climate in this area is characterized by hot, humid summers and generally mild to cool winters.