It connects U.S. Route 1 (US 1) at Hancock with US 1 in Cherryfield running for a distance of 23 miles (37 km).

It heads northeast along Franklin Road passing houses, light industrial facilities, and wooded areas.

It then begins to follow the north side of the furthest reaches of Taunton Bay.

Past the point where SR 200 heads towards the southeast, SR 182 heads northeast, first crossing the Down East Sunrise Trail (formerly the Calais Branch railroad) then passes the town's post office, a cemetery, a club, and additional houses.

After crossing the aforementioned rail trail, SR 182 makes a sweeping curve to the south bypassing a former alignment of the road which stayed closer to the Narraguagus River.