It runs for 35.1 miles (56.5 km) from the town center of Greenwood to an intersection with State Route 133 in Wayne.

SR 219 runs through parts of Oxford, Androscoggin and Kennebec counties.

The two routes share a brief overlap before SR 219 continues northeast into Sumner.

The highway continues through the center of town and intersects with SR 140 just feet shy of the Nezinscot River.

The first highway in Maine designated SR 219 ran between Rumford and South Arm north of Andover in 1928.