SR 224 runs along the Mousam River for most of its length.

SR 224 crosses the Mousam River on Bridge Street, then immediately turns southeast onto Pleasant Street and runs along the northern side of the river, passing several churches, housing developments, and shops in Springvale.

At River Street, SR 224 passes Carl J. Lamb Elementary School and continues onto Shaws Ridge Road.

The highway turns northeast, then again southeast and terminates at US 202/SR 4A just southwest of the Alfred town line.

[2] The entire route is in Sanford, York County.