It is a major east-west corridor in central York County, Maine.

[2] SR 111 continues as Alfred Street, the turnpike link into downtown Biddeford.

Just prior to entering downtown Biddeford, it intersects US 1, then reaches its eastern terminus at the junction with SR 9/SR 208.

been widened to four lanes for a short distance between The Shops at Biddeford Crossing and US 1 due to heavier traffic from nearby shopping centers.

SR 111's entire distance was once designated as part of the now-defunct New England Interstate Route 11, which traversed from Biddeford to Manchester, Vermont (near the Vermont - New York border).