[1] It was founded in the context of the academic annual celebration of the Academy of Sciences and Literature Mainz on 6 November 2015.

Range of competences represented in the network: Mainzed developed the inter-university master's degree program Digital Methods in the Humanities and Cultural Studies in terms of organization and concept.

[13][14] The head of this degree program and director of Mainzed Kai-Christian Bruhn received the academy price of the federal state Rhineland-Palatinate on 5 December 2017 in recognition of his interdisciplinary work in teaching and research.

An example of this is the fishbowl discussion about the topic digitalität und diversität – die Geisteswissenschaften im Jahr 2026 that took place in 2016.

[17] Mainzed has organised similar annual events with national and international guest lecturers like Mercedes Bunz and Joscha Bach.