[11] Hoffmann began her art collecting in the 1980s in New York City in the company of Swiss theatre director Werner Düggelin.
The book contains photos by photographer François Halard of these locations mixed with Rirkrit Tiravanija's use of the British nursery rhyme "This is the House that Jack Built".
[13] As an executive producer, Hoffmann has realised a number of documentary films, including Peggy Guggenheim: Art Addict, Marina Abramovic: The Artist Is Present, Bobby Fischer Against the World, Black White + Gray: A Portrait of Sam Wagstaff and Robert Mapplethorpe, The Party's Over, and Jean-Michel Basquiat: The Radiant Child.
In the 1990s, she worked at Luc Hoffmann's La Tour du Valat, focusing in on the breeding of the Przewalski’s horse (Equus ferus przewalskii) and she helped reintroduce them to their native Mongolia in 2004.
[15] Hoffmann currently is active with her philanthropy at the Rencontres d'Arles in Arles, the Venice Biennale, the Serpentine Galleries in London, and Human Rights Watch in New York.
Located at the Parc des Ateliers in Arles, a former industrial site, LUMA Foundation includes a resource center designed by architect Frank Gehry; various industrial buildings rehabilitated by Annabelle Selldorf; and a public park designed by landscape architect Bas Smets.