In the episode, Kenny becomes addicted to a hallucinogen induced by a new craze in South Park called "cheesing" from being exposed to cat urine, and he experiences hallucinations that are patterned after the 1981 Canadian animated film Heavy Metal, in which he pursues a buxom female in a setting whose motif is based entirely on breasts.
Kenny then experiences a Heavy Metal-esque drug trip driving a rocket-powered, black Pontiac Firebird Trans-Am through space and encountering a woman with large breasts.
At the height of the trip, as Kenny is about to bathe with her, Cartman manages to pin him to the ground and wake him back to reality, where he has been running around and removing his clothes.
After encountering the woman with the large breasts, he is shocked to find Kenny there as well, having found the cats Cartman hid in his attic.
Back in reality, a large audience is watching Gerald and Kenny fight at the playground (still believing themselves to be in the fantasy world), shocking Sheila and embarrassing Kyle.
The female object of Kenny's affections in the episode was portrayed by pornographic actress Lisa Daniels, live-action video of whom was converted to animated form by rotoscoping.
The press conference Gerald has with his wife standing next to him was made to look just like when former New York Governor Eliot Spitzer publicly apologized for being a client in a prostitution ring.
[8] "Major Boobage", along with the thirteen other episodes from South Park's twelfth season, were released on a three-disc DVD and Blu-ray set in the United States on March 10, 2009.
The sets included brief audio commentaries by Parker and Stone for each episode, a collection of deleted scenes, and two special mini-features, The Making of Major Boobage and Six Days to South Park.