Makashule Gana (born 11 August 1983) is a South African politician who is the chief organiser for RISE Mzansi.

He previously served as a member of the Gauteng Provincial Legislature for the opposition Democratic Alliance.

He attended N'wahungani Junior Secondary in 1995 and thereafter moved schools plenty of times.

[7] Gana has been active in campaigning for a national youth subsidy in South Africa, and helped to establish a DA political school with fellow leader Khume Ramulifho in Gauteng’s southern region.

[8] In October 2019, Gana declared his candidacy to succeed Mmusi Maimane as leader of the DA.

[13] In April 2023, Gana was appointed national organiser of social democratic political party RISE Mzansi, under the leadership of Songezo Zibi.