The school occupies the southwestern corner of the university campus and is bordered by the university's School of Education to the north, the School of Fine Art to the east, Makerere Hill Road to the south, the University Main Sports Grounds to the west, and Mary Stuart Hall to the northwest.

This location is approximately 3.5 kilometres (2 mi) northwest of the central business district of Kampala, Uganda's capital and largest city.

[2] The school operates on two campuses: An A’ Level Campus located in Mulawa, Kira Town Council, Wakiso District, approximately 14.5 kilometres (9 mi), north-east of the central business district of Kampala, the capital and largest city of Uganda.

Makerere College School has over the years produced some of best candidates in Kampala District in the national O and A level examinations.

During 2016, the team represented Uganda at the East African Ball Games and was the second-best in the rugby nationals held in Masindi that year.