The Makonie River is a river in Sudbury District in northeastern Ontario, Canada.

[1] It is in the James Bay drainage basin, and is a left tributary of the Chapleau River.

The river begins in geographic Manning Township[2] and flows northeast, passes northeast through the southeast corner of geographic Brutus Township,[3] enters geographic Lipsett Township,[4] and empties into Lipsett Lake.

The river goes north and enters geographic Lloyd Township,[5] heads northeast, and reaches Makonie Lake.

The river flows east, enters geographic Bonar Township,[6] heads northeast to Bonar Lake, then continues northeast and reaches its mouth at the Chapleau River.