It was a vital trade route during the heyday of Malacca Sultanate in the 15th century.

The river starts from the southern end of the Titiwangsa Mountains in the neighbouring state of Negeri Sembilan, at Kampung Orek, Tampin District as the Tampin River which flows south, almost parallel to the Karak-Tampin trunk road (Federal Route FT 9) until Tampin and Pulau Sebang, the latter is beyond the Negeri Sembilan-Malacca border.

[1] Land reclamation projects have extended the river mouth further into the Straits.

This section of the river was developed as a tourist attraction in the city as the Malacca River Cruise, where tourists would hop on a boat and embark on a 45-minute sightseeing tour of the city and its historic core as it cruises along the river, from Pengkalan Rama in the east to Bandar Hilir near the coast of the Strait of Malacca.

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