The sixth season of Malcolm in the Middle premiered on November 7, 2004, on Fox, and ended on May 15, 2005, with a total of 22 episodes.

Frankie Muniz stars as the title character Malcolm, and he is joined by Jane Kaczmarek, Bryan Cranston, Christopher Kennedy Masterson, Justin Berfield and Erik Per Sullivan.

[24] Main cast members Frankie Muniz, Jane Kaczmarek, Bryan Cranston, Christopher Kennedy Masterson, Justin Berfield and Erik Per Sullivan return as Malcolm, Lois, Hal, Francis, Reese and Dewey respectively.

[28] John Leonard of New York wrote, "[T]hose of you who have followed Malcolm to a military academy, a dude ranch, and Afghanistan, through jury duty, hangovers, shoplifting, book clubs, hot tubs, and Oliver North, ought to know better than to doubt for a second the savage savvy of Lois in her solitary splendor.

"[32] In 2020, Ricky Fernandes da Conceição of Goomba Stomp named "Reese Comes Home", "Pearl Harbor", "Dewey’s Opera" and "Billboard" as among the "30 Best Episodes of Malcolm in the Middle".